The Chargers placed WR Malcom Floyd, RB Ryan Mathews and OL Reggie Wells on injured reserve.
Floyd started all 14 games and had 56 catches for 814 yards and five touchdowns. He suffered an ankle injury in Week 15.
Mathews broke his clavicle on Sunday. His year ends with 184 rushes for 707 yards and one rushing touchdown, to go along with 39 catches for 252 yards.
Wells injured his ankle. He had started the last two games for the Chargers.
San Diego signed WR Mike Willie and DE Damik Scafe to the active roster from the practice squad.