Niners fans are hoping that new head coach Jim Harbaugh will bring the success to the Bay Area that former coach Mike Singletary was unable to achieve during his brief tenure.
The 49ers announced their cuts on Saturday, with the most noteworthy player let go being No. 3 QB Josh McCown.
Anthony Dixon capped San Francisco's first two drives with 1-yard touchdown runs and the 49ers beat the San Diego Chargers 20-17 Thursday night.
RB Frank Gore agreed to a three-year extension with the 49ers on Tuesday, Pro Football Talk first reported.
The 49ers activated WR Michael Crabtree from the physically-unable-to-perform list, the team announced Tuesday afternoon.
Matt Schaub recovered after an early interception, leading the Texans on scoring drives in each of their next three series in a 30-7 exhibition rout of the rebuilding 49ers on Saturday night.
The Bengals have acquired S Taylor Mays from the 49ers in exchange for an undisclosed draft choice.
Following a violent incident last Saturday outside Candlestick Park, the 49ers and Raiders will stop playing their annual preseason game.
Two men were shot in the parking lot of Candlestick Park after the Raiders-49ers game Saturday night, according to San Francisco police.
Alex Smith threw for 126 yards and an interception in Jim Harbaugh's home debut, a 17-3 preseason victory by San Francisco over cross-bay rival Oakland.
The 49ers are no longer in the market for a third-string quarterback after reaching an agreement on Wednesday with QB Josh McCown.
Can veteran Alex Smith hold off rookie Colin Kaepernick in the battle for the Niners' starting QB job? That's one of the juicy story lines in the NFC West as PFW looks at all four teams.
Former Vikings and Lions QB Daunte Culpepper worked out with the 49ers on Monday, and he's likely to join the team, Comcast SportsNet Bay Area reported.
New Orleans recorded six sacks and RB Mark Ingram rushed for a 14-yard TD as the Saints defeated the visiting 49ers 24-3 on Friday.
Our 49ers sources put the odds that Dashon Goldson will retain the starting role at free safety after signing a new one-year contract at "about 70 percent."