Alex Smith threw two of his three touchdown passes to Vernon Davis, Frank Gore ran for a score in his second straight 100-yard rushing game and the 49ers beat the Buccaneers 48-3.
49ers new head coach Jim Harbaugh has shown some flaws, but overall he has earned passing marks in the season's first month.
The 49ers placed DL Will Tukuafu on injured reserve and promoted rookie S Colin Jones from the practice squad, the team announced Tuesday.
Here's an early look at the Week Five action, the first shortened (and the bye isn't coming at a great time for a few teams) week of the 2011 NFL season.
Week Four confirmed much of what we had suspected, including that the Lions are for real and Calvin Johnson is the NFL's most dominant player.
Frank Gore's 12-yard run capped a second-half comeback, lifting the 49ers past the Eagles 24-23 on Sunday.
Time for Chris Johnson to step up, dissecting the 3-0 Lions, awaiting the fun that is Ravens-Jets and plenty of other tidbits to look for in Sunday's upcoming games.
Kendall Hunter ran 7 yards for the game's only touchdown with 3:59 to go Sunday, rallying the 49ers to a 13-8 victory in front of the Bengals' smallest crowd for a home opener in 30 years.
Teams with the longest current playoff droughts include the Bills, whose last postseason action, in the '99 season, was ended by the "Music City Miracle."
49ers WR Braylon Edwards is out for an unspecified time period following knee surgery, 49ers head coach Jim Harbaugh said Wednesday.
Tony Romo played through a fractured rib to rally the Cowboys back for a 27-24 overtime win over the 49ers.
With lots of help from Justin Smith and Ray McDonald, his good friends on the Niners' defensive line, OLB Parys Haralson is off to a great start this season.
This week, PFW selects Aaron Rodgers, Brian Urlacher and Ted Ginn, Jr. as its Players of the Week.
Ted Ginn Jr. returned a kickoff and a punt for touchdowns in a minute's span, as the 49ers gave Jim Harbaugh a 33-17 victory over the Seahawks in his NFL debut.
The NFL has fined 49ers WR Braylon Edwards $50,000 for his DWI charge from 2010, but he avoided a suspension.