We start, naturally, with the club facing the toughest slate of opponents based on 2017 win percentage, the Green Bay Packers, whose 2018 foes won 53.9 percent of their '17 games.
The Packers play five prime-time games, including the first "Sunday Night Football" clash of the year, when they'll play host to their oldest rivals, the Bears. Green Bay welcomes back Aaron Rodgers from his broken collarbone, but one of the NFL's more stable franchises faces a lot of other change after firing both coordinators and its general manager in the offseason.
The Packers face a particularly grueling two-week stretch following the bye in Weeks 8-9, when they'll span the country by visiting the NFC West champ L.A. Rams prior to heading to the opposite coast to play the AFC champ Patriots, just the third meeting between future Hall of Famers, Tom Brady and Aaron Rodgers.
The Packers, who play three of their first four at home, must also travel to Seattle two weeks later to play on Thursday Night Football before visiting the division champion Vikings following the "mini bye" in Week 12.