San Francisco (12-3; 8-6-1 ATS) at Seattle (11-4; 7-7-1 ATS) (Sunday night)

Early line: Niners (minus-3 points). Total: (47)

SF 6TH OFF; SEA 26TH DEF

SF 2ND RUN; SEA 24TH vs. RUN

SF 14TH PASS; SEA 27TH vs. PASS

SF 2ND PTS; SEA 21ST PTS ALLOWED

SEA 7TH OFF; SF 2ND DEF

SEA 3RD RUN; SF 17TH vs. RUN

SEA 11TH PASS; SF 1ST vs. PASS

SEA 9TH PTS; SF 8TH PTS ALLOWED

SF T11TH TO/TA; SEA T3RD TO-TA

Seahawks lead all-time series 26-16-0 and have won 11 of last 12 games vs. Niners, including 27-24 win in OT at SF in very tense first game of 2019 season series in Week 10 Monday-nighter on Seahawks PK Jason Myers 42-yard FG with no time remaining in overtime. Seahawks outgained Niners 336-302 in Week 10 thriller, while both defenses registered 5 sacks and a FR returned for a TD and had a combined 7 takeaways. Niners have lost eight straight games in Seattle since winning on Christmas Eve in 2011, including a defeat in the NFC title game following the 2013 season. Another fact worth noting: Since Russell Wilson took over as the Seahawks’ QB in 2012, Seattle is 31-7 in the game following a regular-season loss.

NINERS’ 34-31 Week 16 Saturday-night home win over division-rival Rams on PK Robbie Gould’s 33-yard FG with no time remaining kept SF in control in the race for the NFC's top seed and home-field advantage throughout playoffs.

NINERS still need to win at Seattle Sunday to win the NFC West. Otherwise, they will be relegated to wild-card status.

NINERS QB Jimmy Garoppolo made up for a mostly pedestrian game (16-27-248-1 TD-2 INTs-71.2 QB rating) by delivering two big throws on the final drive after taking his fifth and sixth sacks in Week 16 win.

Garoppolo found WR Kendrick Bourne on an 18-yard pass over the middle to convert the first long third down and then hit WR Emmanuel Sanders behind a blown coverage for 46 yards to set up the winning kick. The NINERS then ran out on the field to celebrate while the Rams were eliminated with the loss.

Rams defense had throttled the NINERS, holding them to four punts, one interception and only two first downs in the second half before SF took over at the 9 midway through the fourth quarter.

Garoppolo hit TE George Kittle on a 36-yard pass to start the drive and then connected with TE Ross Dwelley on a 25-yarder that also featured a Rams personal foul. Three plays later, Garoppolo scrambled on third down to give Kittle time to work free and then found him in the front of the end zone for the TD that gave NINERS a 31-28 lead.

NINERS offense managed only 334 total yards and 4-of-10 3rd-down conversions, while defense allowed Rams 395 total yards and registered zero sacks and one takeaway — an INT by MLB Fred Warner that he returned 46 yards for an INT just before halftime to give SF a 24-21 lead (Warner also had 11 tackles).

NINERS RB Raheem Mostert (11-53-1 rushing) scored on a 16-yard run in 2nd quarter to give him a rushing TD in five straight games. He's the first 49ers player to do that since Derek Loville had a 6-game streak in 1995. The only other SF players to do that are Joe Perry (7 games in 1953-54) and Hugh McElhenny (5 in 1954).

Kittle led NINERS Week 16 receivers with 5-79-1 on 8 targets and a long of 36, and Sanders added 3-61 on 6 targets with a long of 46.

Check status of NINERS S Tarvarius Moore, who left Week 16 game with a concussion; and S Jaquiski Tartt (ribs; DNP in Week 16). DL Dee Ford is expected to miss one more game with a hamstring injury.

In NINERS’Week 10 loss to Seahawks, Garoppolo had 24-46-248-1 TD-1 INT (66.2 QB rating) while getting sacked 5 times and losing 2 fumbles; SF had only 27-87 rushing (3.2 ypc); WR Deebo Samuel had 8-112 receiving on 11 targets with a long of 30, Warner had 2 sacks, a FF and tied for team high in tackles with 10 with RCB Emannuel Moseley, who also had 3 PBs; CB K’Waun Williams had 2 FFs, a half-sack, 2 hurries and 9 tackles; DRT DeForest Buckner had 2 FRs, including one returned 12 yards for a TD, and 5 tackles; and DLE Arik Armstead had 1 ½ sacks, a FF and 3 tackles.

NINERS have 4 Pro Bowl selections: DE Nick Bosa (starter), FB Kyle Juszczyk (starter), TE George Kittle (starter) and CB Richard Sherman (starter).

For a team headed to the playoffs already with 11 victories and still with a shot at the No. 1 seed in the NFC, the SEAHAWKS are in unexpected desperation mode after eyebrow-raising 27-13 Week 16 upset home loss to Cardinals.

In the past 15 days as of this writing, the SEAHAWKS lost their top three running backs and their best offensive lineman to injuries. The foundation of what Seattle wants to be on offense — predicated by a successful run game — has been decimated.

RBs Chris Carson (hip), Rashaad Penny (knee) and C.J. Prosise (arm) are all done for the year. Carson and Prosise were injured in CARDINALS’ loss to Arizona. Penny suffered a torn ACL on his only play of the Week 14 loss to the Rams.

Their need is such that SEAHAWKS have brought back Marshawn Lynch out of retirement to play Sunday night in NFC West championship matchup with San Francisco.

SEAHAWKS have just one healthy running back on roster who has been with the team all season in rookie sixth-rounder Travis Homer. Making matters worse, OLT Duane Brown underwent minor knee surgery on Monday and won’t be back for a few weeks.

The loss of Brown is a major blow for SEAHAWKS. It was highlighted when the Cardinals’ Chandler Jones overwhelmed Jamarco Jones, Brown’s replacement, on his way to four sacks in Seattle’s Week 16 home loss.

At one point in Week 16 loss, the SEAHAWKS were without three of their starting linemen from the beginning of the season — C Justin Britt, OLG Mike Iupati and Brown — not to mention starting TE Will Dissly. Iupati may be in question for the San Francisco game because of a stinger (check status).

SEAHAWKS bombed on both sides of the ball in Week 16 loss, with offense managing just 224 total yards and 1-of-13 3rd-and 4th-down conversions, and the defense surrendering 412 total yards while registering 2 sacks and zero takeaways.

SEAHAWKS’ Wilson had 16-31-169-1 TD-0 INTs (78.6 QB rating) while getting sacked 5 times for 36 yards in losses and had 2-2 rushing with a long of 6.

Carson led SEAHAWKS’ 20-91 ground game with 8-40 rushing and a long of 16 before leaving game with season-ending hip injury.

Meanwhile, SEAHAWKS WRs Tyler Lockett and DK Metcalf were invisible vs. Arizona. Lockett had 1 catch on 8 targets for 12 yards, while Metcalf, who was shadowed by Cardinals CB Patrick Peterson most of the time, dropped his only target of the game.

SEAHAWKS’ run defense has been excellent shutting down some very good running attacks this season, but It was not able to keep Arizona’s Kenyan Drake under control in Week 16 loss. Drake rushed for 166 yards and two touchdowns.

While 80 of those yards came on one run, it was the other 86 yards — many coming in key situations — that were more troubling for SEAHAWKS. The 166 yards rushing were the most allowed to one player this season by Seattle, and the 253 total yards rushing allowed were a season high.

There weren’t many Week 16 performances by SEAHAWKS defense worthy of note, but DE Rasheem Green continues to show promise. Green had 6 tackles, a pass defensed and blocked a FG attempt vs. Cardinals. The 2nd-year DL has two sacks, two forced fumbles and two blocked kicks in the past five games.

In other news on SEAHAWKS’ injury front, head coach Pete Carroll sounded optimistic on his radio show Monday about the status of DE Jadeveon Clowney (core) and CB Shaquill Griffin (hamstring), saying both have a chance to play vs. SF. He was less optimistic about S Quandre Diggs returning from a high-ankle sprain.

In SEAHAWKS’Week 10 win over Niners, Wilson had 24-34-232-1 TD-1 INT (86.9 QB rating) while getting sacked 5 times and 6-53 rushing (8.8 ypc) with a long of 18, Carson had 25-89-1 rushing with a long of 9 and 3-12 receiving on 4 targets with a long of 5, TE Jeff Hollister had 8-62-1 receiving on 10 targets with a long of 13, Metcalf had 6-70 receiving on 10 targets with a long of 25 and a lost fumble, DT Jarran Reed had 1 ½ sacks, a FF and 4 tackles and Clowney had a sack, a FF a FR that he returned 10 yards for a TD and 5 tackles.

SEAHAWKS have 2 initial Pro Bowl selections: ILB Bobby Wagner (starter) and QB Russell Wilson (starter).