We often talk about finding value through injuries when building DFS lineups, and most daily fantasy players probably have memorized more depth charts than they care to admit.
But if Week 13 taught us anything, it's that overlooking injury news on offensive and defensive lines can be a major mistake.
The most notable defensive example was in Miami, where Dolphins running back Kenyan Drake ripped a Denver defensive line that was without its two best run stuffers for 120 yards and a touchdown.
On the offensive line side, Chicago provided the perfect example. Bears guard Kyle Long did manage to start with a bum shoulder, but left at halftime and didn't return. With Long out there at less than 100 percent, running back Jordan Howard had little hope of running between the tackles, even against San Francisco's 30th-ranked run defense.
Now onto the picks:
High: Philip Rivers ($6,800 DraftKings/$8,100 FanDuel): It's likely a week where you want to pay down at quarterback, but Rivers isn't a bad option if you have salary to burn. The veteran is on fire and now gets a soft Washington defense that is making the trip across country.
Mid: Derek Carr ($6,400 DraftKings/$7,700 FanDuel): Remember when Carr torched the Chiefs back in October? Yep, Kansas City's secondary hasn't gotten any better. Fire up Carr with confidence.
Low: Jimmy Garoppolo ($5,500 DraftKings/$7,000 FanDuel): Garoppolo didn't find the end zone in his first start with the 49ers. That's likely to change against a hollowed-out Houston pass defense.
High: Todd Gurley ($8,100 DraftKings/$8,500 FanDuel): Gurley's usage is too much to overlook even in a tough matchup against the Philly run defense. Gurley will need to be heavily involved if the Rams are going to win this potential playoff preview.
Mid: Alfred Morris ($5,500 DraftKings/$6,800 FanDuel): The Giants have completely given up and just made Marshawn Lynch look young and spry with 121 total yards and a touchdown. You can expect a similar outing from Morris.
Low: Peyton Barber ($4,500 DraftKings/$5,500 FanDuel): This hinges on Doug Martin's availability. If Martin misses another week with a concussion, Barber will be in fantastic position to turn in his second straight 100-yard game.
High: DeAndre Hopkins ($8,500 DraftKings/$8,600 FanDuel): Hopkins has received less than eight targets once this season. You can bank on the volume, and he hasn't found the end zone in back-to-back weeks. That's likely to change with the 49ers coming to town.
Mid: Marvin Jones Jr. ($6,800 DraftKings/$7,000 FanDuel): It's going to be hard to ignore Jones even if Matthew Stafford's hand injury forces him to sit out. Against Tampa Bay's secondary, Jones is in consideration whether it's Stafford or Jake Rudock under center.
Low: Marquise Goodwin ($5,100 DraftKings/$5,700 FanDuel): Playing speedy perimeter receivers against Houston's undermanned secondary has been profitable most of the season. The strategy should pay off again with Goodwin.
High: Jimmy Graham ($5,000 DraftKings/$6,900 FanDuel): The price on DraftKings is way too low for a guy that has nine touchdowns since the start of October. Graham is Seattle's best bet to score against Jacksonville.
Mid: Hunter Henry ($4,600 DraftKings/$5,600 FanDuel): The Chargers have apparently rediscovered how fantastic an athlete Henry is. He has 157 yards and a touchdown on 12 receptions over the last two weeks.
Low: Stephen Anderson ($3,200 DraftKings/$4,500 FanDuel): Anderson didn't have more than six targets in a game this season until turning 12 targets into five receptions for 79 yards and a TD in Week 13. His role should be secure with C.J. Fiedorowicz (concussion) likely out.