The Saints placed RB Pierre Thomas (knee) on injured reserve on Saturday.
Thomas didn't practice on Wednesday, Thursday or Friday and had already been ruled out for Sunday's season finale vs. Carolina.
Thomas, 28, rushed for 473 yards and a TD on 105 carries and caught 39 passes for 354 yards and a score in 2012.
The Saints promoted CB A.J. Davis from the practice squad to fill Thomas' roster spot.