Here is Pro Football Weekly's annual All-Injury team, consisting of players who have either suffered season-ending injuries or missed a substantial portion of the season with injuries:
QB Peyton Manning / Colts
Four-time league MVP is a no-brainer if there ever was one. Will he stay in Indy? Could be interesting.
RB Fred Jackson / Bills
Was NFL rushing leader when he went down. Very close call between him and K.C.'s Jamaal Charles.
FB Ovie Mughelli / Falcons
Highly regarded blocking specialist was a 2010 Pro Bowl selection. Combines power with finesse.
WR Andre Johnson / Texans
Lingering hamstring woes have frustrated five-time Pro Bowler to no end.
WR Kenny Britt / Titans
Had a combined 14-271-2 receiving in first two games before going down in Week Three.
TE Tony Moeaki / Chiefs
Was considered one of Matt Cassel's more dependable targets entering season.
OT Jeff Otah / Panthers
A repeat PFW All-Injury starter, Otah landed on I.R. for third time in four years.
OT Russell Okung / Seahawks
A former first-rounder like Otah, Okung was starting to play really well before tearing pectoral.
OG Kris Dielman / Chargers
Loss of Dielman and Marcus McNeill on the left side has been hazardous to Philip Rivers' health.
OG Kory Lichtensteiger / Redskins
'Skins suffered double whammy when both he and TE Chris Cooley went down for count vs. Philly.
C Eric Wood / Bills
Wasted no time becoming a top center, as proven by PFW first-team Midseason All-Pro honor.
DE Luis Castillo / Chargers
Solid defender had started 46 of San Diego's previous 49 regular-season games before injury.
DE Aaron Smith / Steelers
Neck problems of perennially underrated run stopper could be career-ending.
DT Kyle Williams / Bills
Coming off first Pro Bowl appearance, he was Bills' most consistent defender before foot injury.
DT Gerald McCoy / Buccaneers
Another former No. 1 pick bites the dust. Bucs' "D" just not the same without him.
OLB Mario Williams / Texans
Huge loss for Houston. Appeared to have made seamless conversion to Wade Phillips' 3-4 scheme.
MLB Jon Beason / Panthers
Pro Bowler for three consecutive years did not miss a start in first four seasons.
OLB Bryan Thomas / Jets
Dependable 10-year vet's torn Achilles created gaping hole in Jets' defense.
CB Leon Hall / Bengals
Season-ending torn Achilles ended streak of playing in all 73 games since No. 1 selection in '07.
CB Terrell Thomas / Giants
Injured before season, he had a team-high 101 tackles, five picks and four forced fumbles in 2010.
SS Eric Berry / Chiefs
Had proven more than worthy of being fifth overall pick in 2010 draft with Pro Bowl nod as rookie.
FS Nick Collins / Packers
Cohesiveness in Green Bay secondary has been spotty without speedy playmaking safety in mix.
PK Nate Kaeding / Chargers
P Daniel Sepulveda / Steelers
RS Danny Amendola / Rams
LS Patrick Mannelly / Bears