Here is Pro Football Weekly's annual All-Injury team, consisting of players who have either suffered season-ending injuries or missed a substantial portion of the season with injuries:

Offense

QB Peyton Manning / Colts

Four-time league MVP is a no-brainer if there ever was one. Will he stay in Indy? Could be interesting.

RB Fred Jackson / Bills

Was NFL rushing leader when he went down. Very close call between him and K.C.'s Jamaal Charles.

FB Ovie Mughelli / Falcons

Highly regarded blocking specialist was a 2010 Pro Bowl selection. Combines power with finesse.

WR Andre Johnson / Texans

Lingering hamstring woes have frustrated five-time Pro Bowler to no end.

WR Kenny Britt / Titans

Had a combined 14-271-2 receiving in first two games before going down in Week Three.

TE Tony Moeaki / Chiefs

Was considered one of Matt Cassel's more dependable targets entering season.

OT Jeff Otah / Panthers

A repeat PFW All-Injury starter, Otah landed on I.R. for third time in four years.

OT Russell Okung / Seahawks

A former first-rounder like Otah, Okung was starting to play really well before tearing pectoral.

OG Kris Dielman / Chargers

Loss of Dielman and Marcus McNeill on the left side has been hazardous to Philip Rivers' health.

OG Kory Lichtensteiger / Redskins

'Skins suffered double whammy when both he and TE Chris Cooley went down for count vs. Philly.

C Eric Wood / Bills

Wasted no time becoming a top center, as proven by PFW first-team Midseason All-Pro honor.

Defense

DE Luis Castillo / Chargers

Solid defender had started 46 of San Diego's previous 49 regular-season games before injury.

DE Aaron Smith / Steelers

Neck problems of perennially underrated run stopper could be career-ending.

DT Kyle Williams / Bills

Coming off first Pro Bowl appearance, he was Bills' most consistent defender before foot injury.

DT Gerald McCoy / Buccaneers

Another former No. 1 pick bites the dust. Bucs' "D" just not the same without him.

OLB Mario Williams / Texans

Huge loss for Houston. Appeared to have made seamless conversion to Wade Phillips' 3-4 scheme.

MLB Jon Beason / Panthers

Pro Bowler for three consecutive years did not miss a start in first four seasons.

OLB Bryan Thomas / Jets

Dependable 10-year vet's torn Achilles created gaping hole in Jets' defense.

CB Leon Hall / Bengals

Season-ending torn Achilles ended streak of playing in all 73 games since No. 1 selection in '07.

CB Terrell Thomas / Giants

Injured before season, he had a team-high 101 tackles, five picks and four forced fumbles in 2010.

SS Eric Berry / Chiefs

Had proven more than worthy of being fifth overall pick in 2010 draft with Pro Bowl nod as rookie.

FS Nick Collins / Packers

Cohesiveness in Green Bay secondary has been spotty without speedy playmaking safety in mix.

Specialists

PK Nate Kaeding / Chargers

  P Daniel Sepulveda / Steelers

RS Danny Amendola / Rams

LS Patrick Mannelly / Bears