Let's stay away from the major players and focus on second-tier players — the ones we struggle to fill in at our flex positions or final receiver slot. There are no teams on bye in Week 10, so you have your full slate of players available, barring injuries.
QB Matt Cassel, Chiefs (vs. Broncos)
I'm not a Cassel fan, as he has a season average of 202.5 yards for 1.1 TDs and 1.1 interceptions. But the Broncos are allowing opposing QBs 267 yards and 2.3 TDs per game in their past three games. In larger leagues, if you're in need of a quarterback, he's a one-week play.
RB Chris Johnson, Titans (at Panthers)
CJ2K showed some life last week with 110 offensive yards, and has a great matchup against the Panthers. They're allowing 158.7 offensive yards and 1.67 total TDs per game to opposing backs in their past three games. If Johnson is to gain any traction and push ahead, it has to be this week. Start him.
RB Jonathan Stewart, Panthers (vs. Titans)
Stewart has been a disappointment this fantasy season. When healthy, he's usually a solid No. 2 fantasy producer. However, Carolina has become a pass-first, run-second team. He has a three-game average of 66.3 offensive yards and 0.67 TDs. Those are flex numbers at best, but the Titans are allowing 196 offensive yards and 1.3 TDs per game to opposing backs the past three games. Start him.
WR Mike Thomas, Jaguars (at Colts)
Thomas went from a weekly start question to fantasy bench fodder with a three-game average of 2.67 catches for 22.7 yards and zero TDs on 3.7 targets. If he's to come out of that funk, the Colts are the best cure. They're allowing 172 yards and 1.5 TDs per game to opposing wide receivers the past four weeks. He could have fantasy consideration to start in larger leagues.
WR Steve Breaston, Chiefs (vs. Broncos)
Breaston caught 7-115-0 on 11 targets in Week Nine and has a four-game average of 4.75 catches for 67.8 yards and 0.5 TDs on 7.25 targets. The Chiefs aren't an exciting team so it's easy to forget someone like Breaston. The Broncos are allowing an average 197.7 yards and one TD per game to opposing wide receivers in the past three games. Breaston is going back to the slot but will continue to go deep. If you need help, start him.
WR Antonio Brown, Steelers (vs. Bengals)
Brown has been the talk of fantasyland with a three-game average of seven receptions for 92.7 yards and 0.3 TDs on 11.67 targets. The attention is warranted and he will see enough playing time to be a weekly fantasy start as long as he's hot. The Bengals' defense is playing solid this season but over the past three games against opposing wide receivers, it has struggled — allowing 180.7 yards and 06.7 TDs per game to the position. Brown will have opportunities, so start him.
TE Brandon Pettigrew, Lions (at Bears)
Pettigrew is struggling right now with a two-game average of 3.5 catches for 19.5 yards and zero TDs but the Lions' offense looks good with QB Matthew Stafford back on track after a solid performance against the Broncos two weeks ago. The Bears are allowing 58.7 yards and 0.3 TDs per game over their last three games to opposing tight ends, which will give Pettigrew a few opportunities. He's worth starting consideration in larger leagues.
QB Jay Cutler, Bears (vs. Lions)
Cutler is struggling and has yet to live up to expectations since becoming a Bear in 2009. He has a three-game average of 233.7 yards and 1.67 TDs, a far cry from early expectations. The Lions are in the top 10 in least fantasy points allowed to opposing QBs over the past four weeks, allowing 171.7 yards and one TD per game. If you have other options consider them.
RB Marshawn Lynch, Seahawks (vs. Ravens)
Lynch is coming off his best game of the season, rushing for 135 yards and one TD. He has four consecutive games with a TD and a four-game average of 70.3 yards and one TD. However, he's facing the Ravens, who are allowing only 95.3 yards per game and 0.5 TDs to opposing backs the past four weeks. Don't look for much from him. If you can, sit him.
RB Maurice Morris, Lions (at Bears)
Expectations weren't high with Morris but they were higher than his three-game average of 42.7 yards and 0.3 TDs per game. He faces a Bears defense allowing only 76.6 offensive yards and one TD per game to opposing backs in their last three games. Sit him.
WR Marques Colston, Saints (at Falcons)
No one denies the Saints' wide receivers are disappointing as a whole. When healthy, Colston always has an opportunity to explode but in his last three games against the Falcons (two games in 2010 and one in 2009), he averaged only four catches for 33.3 yards and 0.3 TDs. He has a current two-game average of four receptions for 51 yards and no TDs. It's not an attractive matchup with the Falcons allowing 99 yards and 0.3 TDs per game to opposing receivers in their past three games. You should look at other options.
WR Pierre Garcon, Colts (vs. Jaguars)
Garcon's struggles are because of QB Curtis Painter, who is simply not very good. Garcon has a four-game average of 5.25 catches for 42.8 and zero TDs. The Jaguars are allowing only 125.7 yards and 0.67 TDs per game to opposing wide receivers their past three games. Garcon is struggling, and with a tough matchup, sit him.
WR Mike Williams, Bucs (vs. Texans)
The sophomore slump continues for Williams with a season average of 4.6 catches for 45.4 yards and 0.13 TDs on 8.9 targets, and it will continue this week. The Texans are allowing only 96.3 yards and 0.5 TDs per game to opposing wide receivers the past four weeks. Williams is simply not a very good fantasy player right now. Sit him.
TE Fred Davis, Redskins (at Dolphins)
Davis saw a dip in his numbers, catching 4-42-0 on seven targets last week, but he will rebound. It might not be this week though as the Dolphins are allowing only 37.3 yards and 0.25 TDs per game over their past four games. Redskins QB John Beck is struggling, and with the emergence of RB Roy Helu as a receiving option, this might be a week to sit Davis.