There are some interesting plays in larger leagues this week, such as Carson Palmer, who has a nice matchup. But others, such as Tim Tebow, may not be your best option. There are no teams on bye in Week 10, so you have your full slate of players available barring injuries. Also, remember that the Thursday-night games begin this week (Raiders vs. Chargers), so you might need to get your roster set earlier than usual.
QB Carson Palmer, Raiders (at Chargers)
In larger leagues, Palmer makes an interesting play. He threw for 332 yards and three touchdowns last week against the Broncos. With the Chargers allowing opposing quarterbacks 227 yards and 2.67 TDs per game over the last three games, Palmer could exploit this.
RB Maurice Jones-Drew, Jaguars (at Colts)
This is a great matchup for Jones-Drew to post elite numbers. The Colts are one of the league's worst at defending opposing backs. Over the last four weeks, they're allowing 198.0 offensive yards and 1.25 total TDs per game to the position. Those totals include seven receptions, which is great for PPR league owners. This is a matchup he can exploit.
RB Ben Tate, Texans (at Bucs)
You can't ignore the fact Tate's made the most out of his opportunities. In two of his last three games, he's had 100-plus rushing yards and four total on the season. It's about the matchups and the Bucs are allowing 201.7 offensive yards and 1.67 total TDs to opposing backs per game over the past four weeks. Once Arian Foster gets his, Tate should see his opportunities. In larger leagues, this is a matchup you can exploit.
WR DeSean Jackson, Eagles (vs. Cardinals)
Jackson has a three-game average of 2.67 catches for 31 yards and zero TDs in what is already a dismal season. We're entering the second-half and there's always hope. Hope is called the Cardinals, who are allowing a whopping 241.7 yards and 0.67 TDs per game to opposing wide receivers the past three games. He has the matchup and has the ability to exploit it.
WR Santonio Holmes, Jets (vs. Patriots)
Holmes' season is not going the way fantasy owners, nor he for that matter, thought it would. The team is invested in him financially and he's too talented. Combine that with a Patriots defense that can't seem to stop any wide receiver, and he has a matchup to exploit. The Pats are allowing 190.7 yards and 0.67 TDs per game to the position the past three games.
WR Jonathan Baldwin, Chiefs (at Broncos)
The rookie is going to have his ups and downs like last week (1-12-0 on five targets), but he'll have a few solid games here and there. He's supertalented and teams have to focus on Dwayne Bowe and now Steve Breaston. In larger leagues, if you need him, he can exploit this matchup because the Broncos are allowing chunks of yardage. They're allowing 197.7 yards and one TD per game to the position the past three games. Who would believe this a secondary that has CB Champ Bailey?
TE Scott Chandler, Bills (at Cowboys)
Chandler is the touchdown vulture we love to own when he's on because he collects them in bunches. However, he's posting some better yardage numbers, but not much. He has a two-game average of 2.5 catches for 29.5 yards and one TD on 2.5 targets. He's efficient if nothing else, but the Cowboys are allowing a robust 88.8 yards and 0.5 TDs per game to the position the past four weeks. In larger leagues this could be the week you go high-risk, high-reward with a matchup he can exploit.
QB Tim Tebow, Broncos (at Chiefs)
Tebow makes every play exciting to watch, and he's had fantasy success, but he could struggle this week. He's a borderline No. 1 as the Chiefs are only allowing 263.3 passing yards and one passing TD to opposing quarterbacks per game over the past three games. In that span they're also only allowing 11 rushing yards and zero TDs to opposing quarterbacks per game. If you can, avoid this matchup.
RB Beanie Wells, Cardinals (at Eagles)
Wells has his knee to deal with and it's a worry long-term. The Eagles have clamped down from being one of the worst run defenses to one of the better ones against opposing backs over the past three games. They're only allowing 89.3 rushing yards and 0.3 TDs per game in that time. This is a matchup you should avoid.
RB Pierre Thomas, Saints (at Falcons)
Thomas has had a solid two-game run with two touchdowns. However, Chris Ivory came on to rush for 67 yards on 15 attempts and could begin to cut into his touches. There's also the chance Mark Ingram returns. The Falcons have quietly shut opposing backs down this year. They're allowing 101.3 offensive yards and 0.3 TDs per game to the position the past three games. If you have other options, you may want to avoid this matchup.
WR Reggie Wayne, Colts (vs. Jaguars)
Wayne's going through a tough time with QB Curtis Painter and his Week Nine performance (4-30-0) reflects it. He has a tough divisional matchup and Painter's regressing. Add the fact that the Jaguars are only allowing 125.7 yards and 0.67 TDs per game to opposing wide receivers the past three games. This is a matchup to avoid.
WR Lance Moore, Saints (at Falcons)
Moore's on a little bit of a roll with one TD in each of the last two games. He has a tougher matchup this week, as the Falcons are one of the league's best against opposing wide receivers. The Falcons are allowing only 99 yards and 0.3 TDs per game to the position the past four weeks. Moore can score at any time, but with a two-game average of 5-47-1, he may not hit those numbers. You should avoid this matchup.
WR Nate Washington, Titans (at Panthers)
Washington is crumbling as a No. 1 receiver for the Titans and has a three-game average of 2.67 catches for 24 yards and 0.3 TDs on five targets. He also has a hip pointer but should play. Regardless, he's not playing well. While the Panthers can't stop the run, they do keep opposing wide receivers in check. They're only allowing 110.3 yards, but zero TDs per game to the position the past three games. Washington hasn't shown the ability to exploit any matchup, so avoid him for now.
TE Tony Gonzalez, Falcons (vs. Saints)
Gonzo's been a little bit inconsistent the past three weeks, with a three-game average of four catches for 42.3 and 0.3 TDs per game on 5.67 targets. He doesn't have a strong matchup this week, as the Saints are only allowing 30.8 yards and 0.25 TDs to opposing tight ends per game over the last four weeks.