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Colts DT Eric Foster was carted off the field in the final minute of the second quarter of the Monday-night game in Tampa with what appeared to be a serious leg injury.
Foster's leg seemed to get caught underneath teammate Tyler Brayton in the Buccaneers' backfield during a pass play, getting twisted awkwardly.
The fourth-year player from Rutgers came into the game with 12 tackles in the first three games, two of which he started.
The Colts held a 10-7 lead at halftime.