Former Bears WR Tom Waddle led the way in Week 16 among the panelists on the "Pro Football Weekly on TV" show with a 9-6 record, followed closely by PFW publisher/editor Hub Arkush at 8-7. Arkush continues to hold a comfortable lead in the season-to-date standings. All three panelists hit on their lock of the week, and Arkush also leads the way in that category with a 10-5-1 record, with Pro Football Hall of Famer Dan Hampton right on his heels at 10-6.
These picks will be posted on Friday afternoon each week. No Thursday games will be included. Pushes are dropped from each panelist's record.
| Thursday Las Vegas line | Tom Waddle | Dan Hampton | Hub Arkush |
| Sunday ATLANTA -14½ vs. Carolina |
Atlanta |
Atlanta |
Atlanta |
| Pittsburgh -5½ vs. CLEVELAND |
Pittsburgh | Cleveland | Cleveland |
| DETROIT -3½ vs. Minnesota |
Detroit | Minnesota | Detroit |
| GREEN BAY -10 vs. Chicago |
Green Bay |
Green Bay | Green Bay |
| INDIANAPOLIS -10 vs. Tennessee |
Indianapolis | Indianapolis | Indianapolis |
| KANSAS CITY -3½ vs. Oakland |
Oakland | Oakland | Oakland |
| NEW ENGLAND -3½ vs. Miami |
New England |
New England | New England |
| N.Y. Giants -4 vs. WASHINGTON |
N.Y. Giants | N.Y. Giants | N.Y. Giants |
| BALTIMORE -9½ vs. Cincinnati |
Baltimore | Baltimore | Baltimore |
| HOUSTON -1 vs. Jacksonville |
Houston | Houston | Houston |
| NEW ORLEANS -7½ vs. Tampa Bay |
New Orleans |
New Orleans | New Orleans |
| N.Y. JETS -1½ vs. Buffalo |
N.Y. Jets |
N.Y. Jets | N.Y. Jets |
| PHILADELPHIA -6½ vs. Dallas |
Dallas | Philadelphia | Dallas |
| SAN FRANCISCO -6 vs. Arizona |
San Francisco |
San Francisco |
San Francisco |
| San Diego -3½ vs. DENVER |
Denver | San Diego |
San Diego |
| St. Louis -3 vs. SEATTLE |
St. Louis |
St. Louis | St. Louis |
| Tom Waddle | Dan Hampton | Hub Arkush | |
| Lock of the week | Houston | Green Bay |
N.Y. Giants |
| Last week vs. spread | 9-6 | 6-9 | 8-7 |
| Season to date vs. spread | 98-127 | 99-126 | 109-116 |
| Last week's locks | 1-0 | 1-0 | 1-0 |
| Season-to-date locks | 6-10 | 10-6 | 10-5-1 |