Let's take a look at a key matchup in Sunday's Vikings-Bills game at the Metrodome:

Bills RB Fred Jackson vs. Vikings front seven

Jackson has been on a roll lately, rushing for 308 yards and three TDs and catching 14 passes for 154 yards and two TDs the past three games. Now, part of that has been because C.J. Spiller has been battling injuries, and he's slated to play Sunday, but it's not like Spiller has set the NFL on fire since entering the league. Jackson will be the main ballcarrier Sunday, and he is a hard-running shifty performer who has rung up some nice numbers when given the chance. He has developed a bit of a penchant for fumbling this season, something he hasn't done often in the past, so look for the Vikings' defenders to go for strips.

The Vikings completely shut down the Redskins' depleted run game Sunday, but that's not an accurate barometer for this matchup. Although the Vikings' run-defense numbers have been good this season, they are not up to the standards of the group that has been at or near the top of the rankings the past five seasons. That said, all the players up front are healthy and in the lineup, so they'll have the chance to attack a Bills offensive line that has been up and down. One terrific matchup to keep an eye on is Bills ORG Eric Wood, a mauler, against Vikings DT Kevin Williams. Wood handled Lions DT Ndamukong Suh well a few weeks back, and Williams is coming off of one of his best games of the season against the Redskins.