The ride was good for Raiders RB Darren McFadden while it lasted, but a hamstring injury suffered in Week Four has knocked him out for at least this week and possibly longer. That opens the door for Michael Bush, a popular fantasy sleeper this summer before he broke his thumb in the preseason. Now healed, Bush will get the start and likely carry the load Sunday against the Chargers, making him a good fantasy play in all formats. While the Bolts have defended the run well this season, Bush hasn't disappointed when given a heavy dose of action, running for at least 119 yards in the two games he saw 14 or more carries last season. Look for him to take full advantage of his chance.
The Texans' receiving corps continues to be plagued by injury, as now Jacoby Jones joins Andre Johnson on the injury report. Hurting his calf last week, Jones did not take part in any practice this week and is listed as doubtful for Sunday's game vs. the Giants, meaning he's almost certain to sit out. The prognosis is better for Johnson, who was limited in practice and is questionable with an ankle sprain but is likely to return to action after sitting out Week Four. If he's active, he obviously belongs in lineups. On the other sideline, Giants RB Ahmad Bradshaw (ankle) is questionable after being limited all week but was working with the first team on Friday. Barring a setback, he should play Sunday and is a quality fantasy option.
The Colts have decided to make life extra difficult on fantasy owners this week. The team listed a boatload of players as "questionable" on the injury report, with none bigger than WR Austin Collie. Off to a red-hot start with 32-398-5 receiving, Collie was unable to participate in practice Friday with a foot injury and is iffy to face the Chiefs this week. Owners will have to check his status prior to the team's 1 p.m. ET kickoff, as he'll be a game-time decision. If Collie sits, Pierre Garcon, who's also questionable with a bad hamstring, likely would start in his place after fully practicing all week. In the backfield, RB Joseph Addai (knee) is expected to start after putting in a full workout on Friday, while Donald Brown (hamstring) is likely to be sidelined once again. Addai should see a sizable workload against the Chiefs' top-five run defense.
Eagles QB Michael Vick only was able to make it through a few games before his all-out playing style caught up to him, as a hard shot in Week Four resulted in damage to his rib cartilage. Vick has been ruled out for Sunday's contest, which means Kevin Kolb will make a return to the starting lineup at San Francisco. Owners in dire need of a QB might want to give him a look, but he's unlikely to light up the scoreboard. RB LeSean McCoy also hurt a rib last week and is listed as questionable. He returned to practice on Friday, though, and head coach Andy Reid believes the dual-threat back will be good to go. With the Eagles not playing until Sunday night, owners with similar options might want to play it safe and leave McCoy on the bench if they can't afford to wait.
Standout rushers in both Detroit and Cleveland are listed as questionable this week but are expected to suit up. Lions RB Jahvid Best (toe) was limited on Friday but is likely to face the Rams on Sunday. Considering the quality of the matchup, he definitely belongs in lineups. Meanwhile, Browns RB Peyton Hillis (thigh) was unable to practice at all on Friday, but all signs point to his absence being precautionary. With how well Hillis has been playing, owners will want to start him if he's active vs. Atlanta, so be sure to confirm his status Sunday morning. Also for the Browns, QB Jake Delhomme (ankle) could return to the starting lineup after Seneca Wallace started the past three games.
Other notable skill players listed on this week's injury report as questionable include Lions TE Tony Scheffler (concussion), Redskins QB Donovan McNabb (thigh) and Falcons WR Michael Jenkins (shoulder). Those listed as doubtful include Jaguars RB Rashad Jennings (shoulder). Declared out are Broncos RB Knowshon Moreno (hamstring), Lions QB Matthew Stafford (shoulder), Cardinals WR Steve Breaston (knee), Cardinals WR Early Doucet (groin), Titans WR Justin Gage (hamstring), Bears QB Jay Cutler (concussion), Bengals WR Jordan Shipley (concussion), Panthers WR Steve Smith (ankle), Saints RB Pierre Thomas (ankle), Saints RB Reggie Bush (fibula), Raiders WR Chaz Schilens (knee), Colts WR Anthony Gonzalez (ankle) and Redskins RB Clinton Portis (groin).