Stunning fantasy news came from Denver on Friday when it was announced RB Knowshon Moreno would miss Sunday's game. Moreno reportedly pulled his hamstring during Friday's practice, although it wasn't the same hamstring he injured in August. It was obviously bad enough for him to instantly be declared out, so owners need to get him on the bench. There's a chance that the second-year back could miss more than one game, so this is a situation to keep a close eye on. Laurence Maroney and Correll Buckhalter are expected to split carries against the Colts this week, but neither is a recommended fantasy play.
Indianapolis has some injury issues of its own this week. WR Pierre Garcon did not practice at all on Thursday or Friday with a hamstring injury and is listed as questionable for Sunday's contest. Garcon has been a relative nonfactor the first two weeks, so an injury doesn't bode well for his fantasy outlook. With his status shaky, he belongs on benches. WR Austin Collie, meanwhile, has scored in each of the first two games and is a solid start with WR Anthony Gonzalez (ankle) also sidelined. Meanwhile, RB Joseph Addai is also questionable with a knee injury, but he was able to take part in some practice this week and is likely to play. He's just an OK play vs. the Broncos, however, as he'll be sharing carries with Donald Brown.
The Texans have a huge contest on Sunday with the Cowboys, but their best player is listed as questionable. WR Andre Johnson was limited in practice this week after injuring his ankle in Week Two, but the team sounds optimistic that he'll suit up. Head coach Gary Kubiak said he expects Johnson, who had 12-158-1 receiving last week, to play barring any last-minute setbacks. Owners would be wise to monitor his status Sunday morning, but he should be good to go. On the other sideline, Dallas' receiving corps will almost certainly be at full strength with TE Jason Witten (concussion) and WR Dez Bryant (ribs) both labeled as probable. Get ready for a shootout in Houston.
Although Chargers RB Ryan Mathews was optimistic early in the week that he would play Sunday, he's listed as doubtful after sitting out the entire week of practice. Suffering from a high ankle sprain, it's possible that he could be forced to miss multiple outings. In his absence, Mike Tolbert will get the start at Seattle and is a very enticing fantasy option. Tolbert entered last week's contest once Mathews went down and proceeded to rush for 82 yards and two TDs on 16 carries. A big, hard-charging back, he's a good bet to score at least once vs. the Seahawks and is a solid fantasy bet. Darren Sproles will also see increased work on passing downs.
Two backs who have missed the first two weeks are likely to return to face each other this Sunday. The Cardinals' Beanie Wells has been sidelined with a knee injury, and head coach Ken Whisenhunt said Friday that Wells underwent arthroscopic surgery on Sept. 2. But the second-year rusher returned to practice in a limited capacity this week and is likely to play Sunday vs. the Raiders, even though he's listed as questionable. Fantasy owners might want to hold off before reinserting him in their lineup, though, as Tim Hightower could still see the bulk of the work. WR Steve Breaston (knee) is also questionable, so check his status prior to kickoff. Oakland, meanwhile, will get RB Michael Bush (thumb) back this Sunday, though his playing time could be limited with Darren McFadden tearing it up thus far. Keep Bush on your fantasy bench until you see what kind of role he'll have.
Other notable skill players listed on this week's injury report as questionable include Browns RB Jerome Harrison (thigh), Redskins RB Clinton Portis (wrist), Falcons WR Michael Jenkins (shoulder) and Buccaneers RB Kareem Huggins (groin). Those listed as doubtful include Rams WR Laurent Robinson (foot), Browns QB Jake Delhomme and Browns WR Brian Robiskie. Declared out are Steelers QB Dennis Dixon (knee), Lions WR Nate Burleson (ankle), Lions QB Matthew Stafford (shoulder), Saints RB Reggie Bush (leg), Raiders WR Chaz Schilens (knee) and Cardinals WR Early Doucet (groin).