Updated Sept. 26, 2010 @ 12:13 p.m. ET
Posted Sept. 21, 2010 @ 10:35 p.m. ET

Byes: none

1. Aaron Rodgers, Packers at Bears
2. Peyton Manning, Colts at Broncos
3. Drew Brees, Saints vs. Falcons
4. Tony Romo, Cowboys at Texans
5. Matt Schaub, Texans vs. Cowboys
6. Tom Brady, Patriots vs. Bills
7. Donovan McNabb, Redskins at Rams
8. Philip Rivers, Chargers at Seahawks
9. Jay Cutler, Bears vs. Packers
10. Brett Favre, Vikings vs. Lions
11. Eli Manning, Giants vs. Titans
12. Matt Ryan, Falcons at Saints
13. Michael Vick, Eagles at Jaguars — UP
14. Sam Bradford, Rams vs. Redskins
15. Joe Flacco, Ravens vs. Browns
16. Kyle Orton, Broncos vs. Colts
17. Carson Palmer, Bengals at Panthers
18. Bruce Gradkowski, Raiders at Cardinals
19. Josh Freeman, Buccaneers vs. Steelers
20. David Garrard, Jaguars vs. Eagles
21. Alex Smith, 49ers at Chiefs
22. Vince Young, Titans at Giants
23. Derek Anderson, Cardinals vs. Raiders
24. Matt Hasselbeck, Seahawks vs. Chargers
25. Shaun Hill, Lions at Vikings
26. Charlie Batch, Steelers at Buccaneers
27. Chad Henne, Dolphins vs. Jets
28. Mark Sanchez, Jets at Dolphins
29. Matt Cassel, Chiefs vs. 49ers
30. Ryan Fitzpatrick, Bills at Patriots
31. Jimmy Clausen, Panthers vs. Bengals
32. Seneca Wallace, Browns at Ravens
33. Jake Delhomme, Browns at Ravens — INJ (INACTIVE)

Not listed: Dennis Dixon, Steelers; Ben Roethlisberger, Steelers; Matthew Stafford, Lions

The above player rankings are based on expectations for this week only, not for the entire season, taking into account this week's specific matchups and injuries. The initial rankings are compiled before the release of the NFL's early injury report and are updated Thursday to reflect the status of each player.

We base our rankings on the following scoring system: For skill-position players, one point for every 10 rushing/receiving yards, one point for every 30 passing yards, six points for a TD run or catch, four points for a TD pass, two points for a two-point conversion run or catch, two points for a two-point conversion pass. For kickers, three points for FGs of 18-39 yards, four points for FGs of 40-49 yards, and five points for FGs of 50-plus yards. Defensive rankings are based primarily on points allowed, yardage allowed and sack potential.

Glossary of notations

INJ — player has an injury that may affect productivity or availability.
ILL — player has an illness that may affect productivity or availability.
UP — player was moved up on draft board after original posting.
DOWN — player was moved down on draft board after original posting.
Not listed — player is temporarily sidelined due to injury or suspension but otherwise would be ranked.
ACTIVE — on game day, player has been designated active (posted shortly before kickoff, when available).
INACTIVE — on game day, player has been designated inactive (posted shortly before kickoff, when available).

Players and/or notations added after the original posting are shown in boldface.

Note: Remember to check back for late-week and weekend updates, as well as game inactives (when available) in the 90 minutes preceding the 1 p.m. Sunday kickoffs. You'll also find regular updates in Michael Blunda's fantasy report on Sunday mornings.

Watch for Pat Fitzmaurice's "Ten Most Intriguing Players of Week One" on Wednesday and "Fitz's Four-Course Fantasy Feast" on Thursday.